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KMID : 1123920100240030439
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 3 p.439 ~ p.445
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Taraxacum Mongolicum H. Suppress Hepatoprotective Activity by Increasing Liver Antioxidant Enzyme in Carbon Tetrachloride(CCl4)-induced Hepatotoxicity in Rats
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Kim Sung-Hoon
Choi Jong-Won
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Abstract
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Pretreatment with Taraxacum Mongolicum H(TMH) prior to the administration of on significantly prevented the increased serum enzymatic activity of aminotransferase(ALT, AST), gamma-glutamyl transpeptidase(GGT) and bilirubin concentration in dose-dependent manner. In addition, pretreatment with TMH also significantly restored the elevation of hepatic malondialdehyde formation and the depletion of reduced glutathione content in the liver -intoxicated rats. The restoration of microsomal aniline hydroxylase and aminopyrine N-demethylase activities indicated the improvement in functional status of endoplasmic reticulum. -induced hepatotoxicity was also essentially prevented, as indicated by a liver histopathologic study. TMH showed antioxidant effects in -ascorbate-induced lipid peroxidation in rat liver homogenate and in superoxide radical scavenging activity. Our results suggest that the protective effect of TMH against -induced hepatotoxicity possibly involve mechanisms related to its ability to block p450-mediated bioactivation and free radical scavenging effects.
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KEYWORD
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Taraxacum mongolicum H(TMH), carbon tetrachroride, hepatotoxicity
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